Neutral Mutations and Neutral Substitutions in Bacterial Genomes
نویسندگان
چکیده
منابع مشابه
Neutral mutations and neutral substitutions in bacterial genomes.
Molecular evolutionary biologists usually assess the underlying spectrum of mutations within a bacterial genome by examining substitutions that occur at sites believed to be under no selective constraints. Alternatively, bacterial mutation rates can also be estimated in a variety of experimental systems. The two classes of changes occurring in DNA sequences-i.e., mutations and neutral substitut...
متن کاملNeutral Mutations and Repetitive
We have previously shown that computer simulations of processes that generate selectively advantageous changes together with random duplications and deletions give rise to genomes with many different genes embedded in a large amount of dispensable DNA sequence. We now explore the consequences of neutral changes on the evolution of genomes. We follow the consequences of sequence divergences that...
متن کاملNeutral substitutions occur at a faster rate in exons than in noncoding DNA in primate genomes.
Point mutation rates in exons (synonymous sites) and noncoding (introns and intergenic) regions are generally assumed to be the same. However, comparative sequence analyses of synonymous substitutions in exons (81 genes) and that of long intergenic fragments (141.3 kbp) of human and chimpanzee genomes reveal a 30%-60% higher mutation rate in exons than in noncoding DNA. We propose a differentia...
متن کاملDetection of neutral amino acid substitutions in proteins.
The field of biochemical genetics relies heavily upon the detection by electrophoresis of genetically determined variants of proteins. Most of these variants differ by substitutions that involve charged amino acids. Genetic variants of another large class, ones that involve substitutions among neutral amino acids, are not easily detected and are often ignored. Ampholyte isoelectric focusing in ...
متن کاملBirth and death processes with neutral mutations
In this paper, we review recent results of ours concerning branching processes with general lifetimes and neutral mutations, under the infinitely many alleles model, where mutations can occur either at birth of particles or at a constant rate during their lives. In both models, we study the allelic partition of the population at time t. We give closed-form formulae for the expected frequency sp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2003
ISSN: 0737-4038,1537-1719
DOI: 10.1093/molbev/msg229